NEUROPROTECTIVE ACTION OF BUTORPHANOL AND RU-1205 WITH EVALUATION OF THEIR EFFECT O N THE BIOELECTRICAL ACTIVITY OF THE BRAIN IN THE GLOBAL ISCHEMIA MODEL

Since ischemic stroke is an extremely common and dangerous pathology, it important to use drugs with neuroprotective activity. The depth degree of brain damage due ischemia are reflected in its bioelectrical This makes possible the electrocorticography or intracranial electroencephalography (EEG) as a tool for evaluating effectiveness therapy. In present study properties experimental compound RU-1205 kappa-opioid agonist butorphanol were analyzed. effect substances was assessed by measuring extent neurological deficit changes activity rats. Compound (10 mg/kg, i.v.) well reference drug (2,5 restored normal status power EEG signal delta theta frequency bands.